Reconstructing tumor genome architectures
نویسندگان
چکیده
منابع مشابه
Reconstructing tumor genome architectures
It has been observed that cancer genomes typically show not only an increased rate of single nucleotide mutations but also an increase in the number of genome rearrangements. As sequencing whole genomes is still a time-consuming task a method has been proposed for reconstructing the cancer genome from the known sequence of the human genome by finding the breakpoints alongside which the rearrang...
متن کاملReconstructing tumor genome architectures
Although cancer progression is often associated with genome rearrangements, little is known about the detailed genomic architecture of tumor genomes. The attempt to reconstruct the genomic organization of a tumor genome recently resulted in the development of the End Sequence Profiling (ESP) technique, and the application of this technique to human MCF7 tumor cells. We formulate the ESP Genome ...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2003
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btg1074